Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy

Abstract

Bone remodelling suppressants like the bisphosphonates reduce bone loss and slow progression of structural decay. As remodelling removes damaged bone, when remodelling suppression is protracted, bone quality may be compromised predisposing to microdamage accumulation and atypical femoral fractures. The aim of this study was to determine whether teriparatide therapy assists in fracture healing and improves bone quality in patients with bisphosphonate associated atypical femoral fractures.A prospective study was conducted involving 14 consecutive patients presenting during 2. years with atypical femoral fracture. All patients were offered teriparatide therapy unless contraindicated. Age and se..